P083 Inhaled anti-pseudomonal therapy in patients with cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis.
BACKGROUND Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and...
متن کاملPharmacokinetics of inhaled colistin in patients with cystic fibrosis.
OBJECTIVES Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile. PATIENTS AND METHODS We performed a multicentre study in 30 CF patients to assess sputum, serum and urine concentrations after a single dose of 2 million units of colistin administered by inhalation. In a subgroup of patients we also co...
متن کاملIntermittent administration of inhaled tobramycin in patients with cystic fibrosis.
BACKGROUND AND METHODS We conducted two multicenter, double-blind, placebo-controlled trials of intermittent administration of inhaled tobramycin in patients with cystic fibrosis and Pseudomonas aeruginosa infection. A total of 520 patients (mean age, 21 years) were randomly assigned to receive either 300 mg of inhaled tobramycin or placebo twice daily for four weeks, followed by four weeks wit...
متن کاملOutcome of Cystic Fibrosis in Patients with Bronchiectasis
Introduction: Bronchiectasis is a common problem in children especially under 5 years. Early diagnosis of disease and its causes could be useful in early treatment and preventing probable complications. This study aimed at evaluating the cystic fibrosis (CF) in patients with bronchiectasis. Methods: In a cross-sectional study, 374 children with bronchiectasis were studied. The diagnosis was ma...
متن کامل[Anti-inflammatory therapy in cystic fibrosis].
Cystic fibrosis lung inflammation is early, sustained and severe and would justify an anti-inflammatory treatment. At present, the inhaled corticosteroid treatment did not give evidence of efficacy, contrary to the oral presentation, but at the cost of side effects. Azithromycin gives more encouraging results with a good tolerance. New molecules are in the process of validation.
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2018
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(18)30380-1